而对于确诊中枢性性早熟且发育进展明显加速的个体，才应当进行医学干预。在国内外临床实践中，最常用、被各国儿科内分泌指南验证的标准治疗，是使用促性腺激素释放激素类似物（GnRH analogs，常简称 GnRHa）进行阶段性抑制。GnRHa通过持续刺激相关受体，使下丘脑—垂体—性腺轴的“脉冲式激活”被“钝化”，从而降低促性腺激素的活性，进而减少卵巢雌激素分泌，达到减缓青春期进程的效果。
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